What medications interfere with tamoxifen?
Neuroleptics such as thioridazine, perphenazine, and pimozide; certain anti-antimicrobials such as terbinafine and quinidine; and other medications like cinacalcet may also reduce the effectiveness of tamoxifen by inhibiting the conversion of tamoxifen to its active metabolites by the inhibition of the cytochrome P450 …
What is a contraindication for tamoxifen?
For patients taking tamoxifen for breast cancer risk reduction at high risk for breast cancer or with ductal carcinoma in situ, it should be avoided if the patient has a history of deep vein thrombosis (DVT) or pulmonary embolism (PE).
What not eat or drink when taking tamoxifen?
The foods of most concern for women taking tamoxifen are grapefruit and tangerines. Grapefruit is well-known to interfere with numerous medications. Many drug-interaction resources specifically advise that women taking tamoxifen avoid grapefruit.
Is it better to take tamoxifen in the morning or at night?
Tamoxifen may be taken at any time of the day but should be taken at the same time each day. it is within 12 hours of the missed dose.
Who should not take tamoxifen?
Most experts agree that tamoxifen and raloxifene should not be used to reduce breast cancer risk in women who: Have a higher risk of serious blood clots* Are pregnant or planning to become pregnant. Are breastfeeding.
Is tamoxifen an oral chemotherapy?
– It is common to be on therapy for 5-10 years. How is it taken? TAMOXIFEN is a tablet you take by mouth. Take one tablet (20 mg) once daily with or without food at the same time each day.
Can you eat oranges while taking tamoxifen?
Tangerines and other citrus peels contain a chemical called tangeretin, which has been shown to reduce the effectiveness of tamoxifen 41. However, the actual flesh of the fruit contains a lot less tangeretin than the peel, so eating moderate amounts of tangerines and other such citrus fruits should be okay.
Can you take turmeric while on tamoxifen?
Therefore, if you are on tamoxifen it may be best to avoid turmeric and curcumin (particularly in concentrated supplement form), as it can lower the concentration of endoxifen in the body such that it interferes with the therapeutic impact of the drug.
What are the long term side effects of tamoxifen?
Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.