Is Ebixa and memantine same?
Ebixa is a medicine that contains the active substance memantine hydrochloride. It is available as tablets (5 mg, 10 mg, 15 mg and 20 mg). Ebixa is also available as an oral solution, which is supplied with a pump that delivers 5 mg memantine hydrochloride with each activation.
What is memantine Namenda used for?
Memantine is used to treat the symptoms of Alzheimer’s disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain.
What is the drug Ebixa used for?
Ebixa is used to treat moderately severe to severe Alzheimer’s disease (AD). AD can be described as a general decline in all areas of mental ability. Ebixa belongs to a group of medicines called N-methyl-D-aspartate (NMDA) receptor antagonists.
Does memantine prolong life?
Medications containing the drug memantine are supposed to help people who have Alzheimer’s disease remember things and better manage their daily tasks. Studies show that memantine can somewhat delay the worsening of cognitive (mental) performance. Other abilities important in daily life may also last longer.
What is the chemical formula for memantine hydrochloride?
Namenda® (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: H3C CH3 NH2 HCl The molecular formula is C12H21N•HCl and the molecular weight is 215.76.
What are the efficacy measures of memantine Ebixa?
Clinical global impressions (CGI), and Mini Mental Status Examination (MMSE) were performed during the treatment period (after 2, 4, and 28 weeks). Efficacy measures also included the ADCS-Activities of Daily Living scale (ADCS-ADL).
How does memantine work to treat Alzheimer’s disease?
This medication works by blocking the action of a certain natural substance in the brain ( glutamate) that is believed to be linked to symptoms of Alzheimer’s disease. Memantine is available under the following different brand names: Namenda XR, and Namenda. Dosage Considerations – Should be Given as Follows:
How is memantine a NMDA receptor blocker?
It is characterized as a voltage-sensitive open-channel NMDA receptor blocker that antagonizes NMDA receptor-mediated inward currents in vitro with an IC50 of 1-3 microM. In animal models, memantine displays both neuroprotective (antiexcitotoxic) and cognition-enhancing properties at therapeutically relevant concentrations.