Is mechlorethamine still used?
Mechlorethamine is the original nitrogen mustard and is still used today in the treatment of Hodgkin’s disease and other lymphomas (Newton, 2006a). Used at conventional IV doses, mechlorethamine does not cause any CNS toxicity.
What class of drug is mechlorethamine?
Mechlorethamine gel is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells.
What is mechlorethamine made up of?
About: Mechlorethamine (Mustargen®, Nitrogen Mustard) It used to be called nitrogen mustard, and you may still hear it called this. It is a derivative of nitrogen gas and was first used in World War I as a chemical warfare agent.
Who makes carmustine?
Production. Carmustine for injection was marketed under the name BiCNU by Bristol-Myers Squibb and now by Emcure Pharmaceuticals.
What is antineoplastic material?
Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. These drugs come in many forms. Some are liquids that are injected into the patient and some are pills that patients take.
What are antimetabolite drugs?
Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. They affect DNA synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid).
What is Lomustine used for?
Lomustine is used to treat certain types of brain tumors. Lomustine is also used with other medications to treat Hodgkin’s lymphoma (Hodgkin’s disease) that has not improved or that has worsened after treatment with other medications. Lomustine is in a class of medications called alkylating agents.
How much does carmustine cost?
BiCNU (carmustine) is a member of the alkylating agents drug class and is commonly used for Brain Tumor, Glioblastoma Multiforme, Hodgkin’s Lymphoma, and others….Intravenous Powder For Injection.
| Quantity | Per unit | Price |
|---|---|---|
| 1 | $2,762.94 | $2,762.94 |
Is antineoplastic a drug class?
The antineoplastic agents or anticancer drugs represent a large and diverse class of medications. They generally have limited but important uses, and often have significant hepatotoxicity.
What kind of chemical is mechlorethamine used for?
Mechlorethamine belongs to the group of nitrogen mustard alkylating agents. It has been derivatized into the estrogen analogue estramustine phosphate, used to treat prostate cancer. It can also be used in chemical warfare where it has the code-name HN2. This chemical is a form of nitrogen mustard gas and a powerful vesicant.
What kind of mustard is mechlorethamine or chlormethine?
Chlormethine (INN, BAN), mechlorethamine (widely used in the US, not the USAN, however) also known as mustine and HN2 and in former USSR known as Embichin is a nitrogen mustard sold under the brand name Mustargen.
Is there a link between mechlorethamine and acute injury?
Given parenterally in combination with other antineoplastic agents it was associated with low rates of serum enzyme elevations during therapy, but mechlorethamine has not been implicated specifically in cases of acute, clinically apparent injury. Mechlorethamine is a nitrogen mustard and an organochlorine compound.
How does mechlorethamine affect the replication of DNA?
Mechlorethamine, as an alkylating agent, interferes with DNA replication and transcription of RNA, and ultimately results in the disruption of nucleic acid function. The alkylating agent, nitrogen mustard (HN2), is thought to cause apoptosis through production of free oxygen radicals.