What does CMV DNA detected mean?
Viral detection. A positive CMV DNA test may mean CMV is present and you have, or the newborn tested, has an active infection. High levels of viral DNA may indicate a more severe infection with serious symptoms.
What is CMV Quant?
CMV is also the most common cause of congenital viral infection in humans. Quantitative PCR methods may be useful in monitoring CMV replication in immunosuppressed patients or in determining the viral load of CMV in amniotic fluid. This is a quantitative molecular test, with a linear range of 200-2,000,000 IU/mL.
How did I get CMV virus?
People with CMV may pass the virus in body fluids, such as saliva, urine, blood, tears, semen, and breast milk. CMV is spread from an infected person in the following ways: From direct contact with saliva or urine, especially from babies and young children.
What is the general information code for CMV?
General Information Code Name CMVQNS CMV Quant Specimen Description CMQNR CMV Quant Result CMLOG CMV DNA IU/mL (Log10) CMVQNI CMV Quant Interpretation
What is the limit of quantitation for CMV?
The limit of quantitation (the minimum virus level that gives a positive result in 95% of replicates) is 50 IU/mL (1.70 log IU/mL). The assay is standardized against the 1st World Health Organization (WHO) International Standard for Human Cytomegalovirus for Nucleic Acid Amplification Techniques (NIBSC 09/162).
What is the international standard for cytomegalovirus amplification?
The assay is standardized against the 1st World Health Organization (WHO) International Standard for Human Cytomegalovirus for Nucleic Acid Amplification Techniques (NIBSC 09/162). Results are reported in International Units per milliliter (IU/mL).
Where does the majority of CMV resistance come from?
The vast majority of resistance results from specific mutations in two genes in CMV. The most common mutations occur in the gene UL97 and can confer resistance to ganciclovir.