What does SHH signaling do?
The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.
How does SHH pathway work?
SHH can signal in an autocrine fashion, affecting the cells in which it is produced. When SHH reaches its target cell, it binds to the Patched-1 (PTCH1) receptor (Process “3” on Figure 5, the blue molecule). In the absence of ligand, PTCH1 inhibits Smoothened (SMO), a downstream protein in the pathway (Process “4”).
What type of signaling is SHH?
Shh is not only considered as a local short-range signalling molecule but it has also been implicated in regulating ventral patterning in the neural tube.
Why is HH important?
The Hh signaling pathway plays an important role in the embryonic development of the cerebellum, and consequently, its role in the formation of MB is not surprising. Purkinje cells release SHh, which induces mass proliferation of granule neuron progenitor (GNP) cells and delays neural differentiation.
Is Sonic a mutant?
In his Archie Comics continuity, it was eventually revealed that Sonic the Hedgehog was a mutant with human DNA, and that Mobius was a future Earth.
Who discovered SHH?
Though some sources credit Dr. Cliff Tabin with naming the Sonic hedgehog gene, it actually came from another scientist in his lab. After discovering the hedgehog gene in some fruit flies (so named for the spiky projections on their backs), Tabin and his coworkers were tasked with naming related genes.
Who named Shh?
The story of Shh is told a lot, but it’s surprisingly difficult to track down the real story. Though some sources credit Dr. Cliff Tabin with naming the Sonic hedgehog gene, it actually came from another scientist in his lab.
How does cyclopamine inhibit Shh?
Mechanism. Cyclopamine impacts embryonic development by hindering the sonic hedgehog (Shh) pathway. Cyclopamine has a high affinity for Smoothened – and upon binding, inhibits the signal. Even though Shh may inhibit Patched, Smoothened cannot signal in the presence of Cyclopamine and thus the pathway is interrupted.
Is Sonic hedgehog a transcription factor?
The sonic hedgehog transcription pathway has also been linked to the formation of specific kinds of cancerous tumors, including the embryonic cerebellar tumor and medulloblastoma, as well as the progression of prostate cancer tumours. Sonic hedgehog has also been shown to act as an axonal guidance cue.
Who named SHH?
Is Sonic a human?
Sonic is a blue anthropomorphic hedgehog who can run at supersonic speeds and curl into a ball, primarily to attack enemies. Programmer Yuji Naka and artist Naoto Ohshima are generally credited with creating Sonic. Most of the games are developed by Sonic Team.
How did Shh get its name?
The mammalian hedgehog protein, sonic hedgehog (SHH) was named by a postdoc in Cliff Tabin’s lab who took inspiration from a comic book his daughter was reading. SHH is involved in the hedgehog signalling pathway, which is a key regulator of all bilateral animal development.