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What is beta E thalassemia?

What is beta E thalassemia?

Beta thalassemia is a blood disorder that reduces the production of hemoglobin . Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body.

Is Hb E disease thalassemia?

Hemoglobin E/beta thalassemia disease is a lifelong disease that can cause serious health problems. If both parents have hemoglobin E trait, there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin E disease. People with hemoglobin E may have health problems and mild anemia.

Is HbE same as beta thalassemia?

Hemoglobin E – beta-thalassemia (HbE – BT) is a form of beta-thalassemia (see this term) that results in a mild to severe clinical presentation ranging from a condition indistinguishable from beta-thalassemia major to a mild form of beta-thalassemia intermedia (see these terms).

What is Hb E disease?

Listen. Hemoglobin E (HbE) disease is a mild, inherited blood disorder characterized by an abnormal form of hemoglobin, called hemoglobin E. People with this condition may have very mild anemia , but the condition typically does not cause any symptoms.

Can thalassemia be cured?

Bone marrow and stem cell transplant from a compatible related donor is the only treatment that can cure thalassemia. It is the most effective treatment.

How long do thalassemia patients live?

“Most thalassaemia patients would live up to the age of 25 to 30 years. Improved facilities will help them live up to the age of 60,” said Dr Mamata Manglani, head of pediatrics, Sion hospital.

Which hemoglobin is increased with thalassemia?

The distinguishing finding in beta thalassemia is a hemoglobin electrophoresis with the finding of elevated Hgb A2 and F. Both will be increased in beta thalassemia trait without iron deficiency, and will be normal or decreased in alpha thalassemia and isolated iron deficiency anemia.

What are the types of beta thalassemia?

Beta thalassemia has three main forms – minor, intermedia and major, which indicate the severity of the disease. Individuals with beta thalassemia minor usually do not have any symptoms (asymptomatic) and individuals often are unaware that they have the condition.

What is the treatment for beta thalassemia?

Treatment for beta thalassemia may include: Regular blood transfusions. Medications (to decrease amount of iron in the body, called chelation therapy) Surgical removal of the spleen (if necessary)

How is B thalassemia diagnosed?

The diagnosis of β-thalassemia relies on measuring red blood cell indices that reveal microcytic hypochromic anemia, nucleated red blood cells on peripheral blood smear, hemoglobin analysis that reveals decreased amounts of HbA and increased amounts of hemoglobin F (HbF) after age 12 months, and the clinical severity …

What is the normal range of Hb E?

Laboratory Findings. The steady-state hemoglobin levels in HbE β thalassemia range widely between the different phenotypes, from 3 g/dl or less to as high as 11 g/dl.

What are the 3 types of hemoglobin?

The most common are:

  • Hemoglobin S. This type of hemoglobin is present in sickle cell disease.
  • Hemoglobin C. This type of hemoglobin does not carry oxygen well.
  • Hemoglobin E. This type of hemoglobin is found in people of Southeast Asian descent.
  • Hemoglobin D.

What are the effects of thalassemia?

Various long term effects due to thalassemia involve severe anemia, splenomegaly, hepatomegaly, bone deformation, increased risk of fracture, iron toxicity and organ failure.

What is thalassemia trait?

Thalassemia Trait. Thalassemia is a genetic disease. This means that a person can only get thalassemia disease or trait by inheriting the genes for thalassemia from their parents. Genes determine what we look like, such as hair color, and are also responsible for many diseases.

What is the history of thalassemia?

Thalassemia, also known as Mediterranean anemia, is an ancient group of diseases that have existed for over 7,000 years. The name thalassemia comes from the ancient Greek word for sea, thalassa , as the ancients believed it was an “illness that came from the sea”.

What is alpha thalassemia vs. Beta thalassemia?

There are two major forms of thalassemia as alpha thalassemia and beta thalassemia. In alpha thalassemia, there is a decrease in the number of alpha globin chains whereas in beta-thalassemia it is the number of beta globin chains that goes down. This is the key difference between alpha and beta thalassemia.