What is rivastigmine tartrate used to treat?
Rivastigmine is used to treat mild to moderate dementia caused by Alzheimer’s or Parkinson’s disease. Rivastigmine is not a cure for Alzheimer’s or Parkinson’s disease. Rivastigmine may also be used for purposes not listed in this medication guide.
How is rivastigmine metabolized?
Metabolism: Rivastigmine is rapidly and extensively metabolized, primarily via cholinesterase-mediated hydrolysis to the decarbamylated metabolite. Based on evidence from in vitro and animal studies, the major cytochrome P450 isozymes are minimally involved in rivastigmine metabolism.
Where is rivastigmine metabolized?
Rivastigmine
| Clinical data | |
|---|---|
| Metabolism | Liver, via pseudocholinesterase |
| Elimination half-life | 1.5 hours |
| Excretion | 97% in urine |
| Identifiers |
What is the mechanism of action of rivastigmine?
The exact mechanism of rivastigmine’s action is unknown, however it is thought to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase.
What are the benefits of taking rivastigmine?
Rivastigmine is used to treat confusion (dementia) related to Alzheimer’s disease and to Parkinson’s disease. Rivastigmine does not cure either of these diseases, but it may improve memory, awareness, and the ability to perform daily functions.
What are the side effects of rivastigmine?
Rivastigmine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea.
- vomiting.
- loss of appetite.
- heartburn or indigestion.
- stomach pain.
- weight loss.
- diarrhea.
- constipation.
Which is better donepezil vs rivastigmine?
The donepezil treated group evidenced significantly better performance on measures of working memory and attention when compared to the no treatment control group and also performed significantly better than the rivastigmine group on three of our four measures.