What is the KLF4 gene?
KLF4 (Kruppel Like Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Secretory Meningioma and Cerebral Cavernous Malformations. Among its related pathways are Developmental Biology and Regulation of Wnt-mediated beta catenin signaling and target gene transcription.
What protein does KLF4 code for?
In humans, the protein is 513 amino acids, with a predicted molecular weight of approximately 55kDa, and is encoded by the KLF4 gene. The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog….KLF4.
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What does KLF4 stand for?
Krüppel-like factor 4
Abstract. Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation.
Is KLF4 an oncogene?
KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.
What does myc gene stand for?
MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement. Among its related pathways are IL-2 Pathway and Endometrial cancer.
What is the function of Oct4?
Oct4 mainly functions through the activation of pluripotency-associated and self-renewal-associated genes, while simultaneously repressing genes that promote differentiation, in coordination with other pluripotency factors and coregulators.
Is Sox2 a protein?
Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.
Is KLF4 a transcription factor?
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation.
What does the presence of the KLF4 protein prevent stem cells from doing?
Embryonic stem (ES) cells are regulated by a network of transcription factors that maintain the pluripotent state. Posttranslational modification of KLF4 destabilizes the protein as cells exit the pluripotent state, and mutations that prevent this destabilization also prevent differentiation.
What cancers is myc associated with?
MYC is documented to be involved broadly in many cancers, in which its expression is estimated to be elevated or deregulated in up to 70% of human cancers. High levels of MYC expression have been linked to aggressive human prostate cancer and triple negative breast cancer (Gurel et al., 2008; Palaskas et al., 2011).
Where is the MYC gene found?
In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes).
Is Oct4 a gene?
The Oct4 protein, encoded by the Pou5f1 gene was the very first master gene, discovered 25 years ago, to be absolutely required for the stemness properties of murine and primate embryonic stem cells.
What is the function of the KLF4 gene?
Entrez Gene Summary for KLF4 Gene. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin.
How is Kruppel like factor 4 ( KLF4 ) regulated?
Studies show that the Kruppel like factor 4 (KLF4) gene undergoes alternative splicing, and the protein products of certain transcripts antagonize wild-type KLF4 function, suggesting an additional layer of regulation of KLF4 function [Review].
Which is part of the KLF family of transcription factors?
KLF4 is a member of the KLF family of transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming.
Which is part of the Wnt signaling pathway is Klf4?
In the intestinal epithelium, KLF4 is an important regulator of Wnt signaling pathway genes of genes regulating differentiation.