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What is Transgradient Palmoplantar Keratoderma?

What is Transgradient Palmoplantar Keratoderma?

Diffuse hereditary palmoplantar keratoderma ‘Transgradient’ is a term used to describe the extent of the skin thickening: Non-transgradient keratodermas do not extend beyond the palms on the hands and the sole on the feet.

Is Palmoplantar Keratoderma painful?

Pain is a prominent symptom in hereditary palmoplantar keratodermas (PPKs). Pain in patients with PPK can be difficult to treat. Pain mechanisms in PPKs are poorly understood.

How do you stop Palmoplantar?

Possible treatment options include:

  1. Topical steroids applied directly to the blisters.
  2. Emollients (moisturizers)
  3. Retinoid medications such as Acitretin (vitamin A derivative)
  4. Ultraviolet light (phototherapy, UVB or PUVA)
  5. Combination of retinoid and phototherapy.

Which is the best treatment for palmoplantar keratoderma?

Treatment options may depend on the specific type of PPK a person has and may include: Saltwater soaks. Emollients. Paring (cutting away layers of skin) Topical keratolytics (useful for people with limited keratoderma) Topical retinoids (this is often limited by skin irritation) Systemic retinoids (acitretin)

What kind of retinoids can I use for keratodermas?

Topical retinoids, such as tretinoin (0.05% gel and 0.1% cream), are effective, but treatment can cause irritation of the surrounding skin. Topical steroids can be considered, with or without keratolytics, in conditions where there is an inflammatory component.

Which is a rare disorder associated with extra palmoplantar skin?

(Diffuse PPK is associated with extra palmoplantar skin involvement in several inherited disorders of cornification. The more common conditions are outlined below.) Mal de Meleda is a rare disorder seen in approximately 1 in 100,000 people. It was initially observed in inhabitants of the Adriatic island of Meleda (Miljet).

What kind of keratolytics are used for PPK?

Topical keratolytics, such as 6% salicylic acid in white soft paraffin, or a gel of 6% salicylic acid in 70% propylene glycol. Benzoic acid compounds. Oral retinoids. Diffuse epidermolytic PPK is the most common type of hereditary PPK. It has an autosomal dominant inheritance traced to KRT9 keratin.