Which of the following drug belongs to Ketolides?
Ketolides (telithromycin) are derivatives of erythromycin A specifically designed for activity against bacteria responsible for community-acquired respiratory tract infections. Telithromycin is a 14-membered macrolide with a 3-keto group substitution.
Are Ketolides macrolides?
Ketolides are a new class of antibacterial drugs (derived from macrolides) designed specifically to fight respiratory tract pathogens that are resistant to macrolides.
What are some common macrolides?
Macrolides are a class of antibiotic that includes erythromycin, roxithromycin, azithromycin and clarithromycin. They are useful in treating respiratory, skin, soft tissue, sexually transmitted, H. pylori and atypical mycobacterial infections.
Are Ketolides bactericidal?
Ketolides bind to the bacterial 50S ribosomal subunit and inhibit RNA-dependent protein synthesis. They are bacteriostatic at low concentrations and bactericidal at high concentration, so basically exhibit concentration dependent killing.
How do Ketolides work?
Ketolides have a mechanism of action very similar to erythromycin A from which they have been derived. They potently inhibit protein synthesis by interacting close to the peptidyl transferase site of the bacterial 50S ribosomal subunit. Ketolides bind to ribosomes with higher affinity than macrolides.
Is amoxicillin a macrolide?
Azithromycin is in the macrolide category of antibiotics, while amoxicillin is in the beta-lactam/penicillin category. They work in different ways and have some differences, such as in indications and drug interactions.
Who should not take macrolides?
Contraindications to Macrolides Macrolides are contraindicated in patients who have had an allergic reaction to them.
What do Ketolides treat?
Ketolides are used to treat community-acquired bacterial pneumonia. Other respiratory tract infections were removed as indications when it was recognized that use of telithromycin can result in hepatitis and liver failure.
How are ketolides different from other macrolides?
The ketolides: a critical review Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well a …
How are ketolides used in the respiratory tract?
Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well a … The ketolides: a critical review
How are ketolides different from erythromycin A and B?
The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well a … Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides.
How are ketolide antibiotics different from other antibiotics?
Ketolides are a new generation of macrolide antibiotics designed to overcome issues with bacterial resistance to macrolides. They are semi-synthetic antibiotics derived from erythromycin (macrolide antibiotic) and the changes give ketolides a broader spectrum of activity.