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What does multidrug resistance protein do?

What does multidrug resistance protein do?

Multidrug Resistance Protein (MRP) confers resistance to natural product drugs when overexpressed in cultured cells. It has also been detected in human tumors and in some cases, expression has been correlated with a poor response to chemotherapy.

Which proteins helps in disease resistance?

Protein Similar proteins Species
P59584 Disease resistance protein RPP8 (Fragment) ARATH
Resistance protein RPP8-like protein (Fragment) ARATH
Uncharacterized protein ARATH

What type of protein is the Multidrug Resistance Protein?

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

How many different types of multidrug resistance proteins are there?

Genetic studies have divided the ABC transporter superfamily into seven subfamilies based on sequence similarities (1). Nine human multidrug resistance proteins (MRPs) are generally members of subfamily C in the ABC superfamily.

What is Bcrp substrate?

Summary. ABCG2, more commonly referred to as BCRP (Breast Cancer Resistance Protein), is an efflux transporter that serves two major drug transport functions. Firstly, it restricts the distribution of its substrates into organs such as the brain, testes, placenta, and across the gastrointestinal tract (GIT).

Why is eating enough protein important?

Your body needs protein to stay healthy and work the way it should. More than 10,000 types are found in everything from your organs to your muscles and tissues to your bones, skin, and hair. Protein is also a critical part of the processes that fuel your energy and carry oxygen throughout your body in your blood.

Which protein helps in disease resistance albumin or fibrinogen?

Coagulants, mainly fibrinogen, aid in blood clotting. Plasma proteins, such as albumin and globulin, that help maintain the colloidal osmotic pressure at about 25 mmHg.

What do ABC proteins do?

Function. ABC transporters utilize the energy of ATP binding and hydrolysis to transport various substrates across cellular membranes. The third subgroup of ABC proteins do not function as transporters, but are rather involved in translation and DNA repair processes.

What is an example of Symport?

An example of a symporter is moving glucose up its concentration gradient (often referred to as uphill movement) by using the energy from the movement of sodium ions that are moving down their gradient (downhill movement).

What is the role of are protein in disease resistance?

Disease resistance (R) protein that specifically recognizes the AvrRpm1 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.

What is the specificity of activated protein C resistance?

The activated protein C resistance phenotype is typically diagnosed with an activated partial thromboplastin time-based assay, which detects factor V:Q506-dependent as well as acquired activated protein C resistance. However, the sensitivity and specificity for the factor V mutation are usually below 90%.

Why is BCRP called breast cancer resistance protein?

The new transporter was named breast cancer resistance protein (BCRP) because it was isolated from multidrug-resistant human breast cancer cells [5]. Two other groups reported finding a similar cDNA at approximately the same time, which were designated as ABCP [6]or MXR [7], respectively.

How is V Leiden related to activated protein C?

Factor V Leiden/Activated Protein C Resistance. Activated protein C resistance was first described in 1994, when patients with venous thrombosis were found to be resistant to the normal anticoagulant effects of activated protein C. This protein inhibits coagulation by proteolytically inactivating factors Va and VIIIa.