What genes does Nrf2 activate?
Nrf2 increases the supply of cysteine by directly activating Slc7a11, the gene encoding the xCT subunit of system xc− (141). In addition to GSH synthesis, Nrf2 plays a role in GSH maintenance.
Is Nrf2 a gene?
NFE2L2 (Nuclear Factor, Erythroid 2 Like 2) is a Protein Coding gene. Diseases associated with NFE2L2 include Immunodeficiency, Developmental Delay, And Hypohomocysteinemia and Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Transcriptional activation by NRF2 and Toll-like Receptor Signaling Pathway.
What is Nrf2 function?
The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants. Nrf2 controls the basal and induced expression of an array of antioxidant response element-dependent genes to regulate the physiological and pathophysiological outcomes of oxidant exposure.
Is Nrf2 good or bad?
In summary, there is abundant evidence that activation of NRF2 can be a safe and effective strategy for the chemoprevention of cancer and many other diseases. People have been safely ingesting NRF2 activators in their diet for millennia.
What is Nrf2 good for?
NRF2 (or NFE2L2) is a protein, naturally found within the body. It’s job is to help regulate the work of antioxidant proteins that can help protect against oxidative damage. This oxidative damage can be triggered by injury and inflammation and involves the production of free radicals.
Which is a target gene for transcription factor Nrf2?
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
What is the function of Nrf2 in the liver?
NF-E2–related factor 2 (Nrf2) is an essential transcription factor that regulates an array of detoxifying and antioxidant defense gene expression in the liver. It is activated in response to oxidative stress and induces the expression of its target genes by binding to the antioxidant response element (ARE).
How is Nrf2 related to the antioxidant response?
The nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor of the antioxidant response via regulating gene expression with the antioxidant responsive element. Under normal conditions, NRF2 is quickly degraded, mainly via the Kelch-like ECH-associated protein 1 (Keap1)-mediated pathway.
How does p62 contribute to the activation of Nrf2?
Induction of the p62 gene by oxidative stress is mediated by NF-E2-related factor 2 (NRF2) and, at the same time, p62 protein contributes to the activation of NRF2, but hitherto the mechanisms involved were not known.