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What is Chou Talalay method?

What is Chou Talalay method?

The Chou-Talalay method for drug combination is based on the median-effect equation, derived from the mass-action law principle, which is the unified theory that provides the common link between single entity and multiple entities, and first order and higher order dynamics.

What does a combination index mean?

2 Combination index analysis. Combination index provides a quantitative measure of the extent of drug interaction at a given effect level (5, 6, 15).

What is CompuSyn?

CompuSyn for Drug Combinations: PC Software and User’s Guide: A Computer Program for Quantitation of Synergism and Antagonism in Drug Combinations, and the Determination of IC50 and ED50 and LD50 Values, ComboSyn Inc, Paramus, (NJ), 2005.

What is the median-effect?

Median-effect principle for dose-effect analysis. This method involved plotting dose-effect curves for each agent and its combination with other agents by using the median-effect equation: fa/fu = (D/Dm)m (equation 1).

What is FA CI plot?

The Combination Index Plot Entering a series of “dose (D) and effect (fa)” into computer for each drug alone and their combinations, the software will automatically simulate the CI values at different fa levels in seconds, based on the CI algorithm. This plot is also called the Fa-CI plot or the Chou-Talalay plot.

How is drug synergy calculated?

It is calculated as follows: CDI=AB/(A×B). AB is the ratio of the 2-drug combination group to the control group and A or B is the ratio of the single drug group to the control group. All the best!

What is the Chou-Talalay method for drug combination?

The Chou-Talalay method for drug combination is based on the median-effect equation, which provides the theoretical basis for the combination index (CI)-isobologram equation that allows quantitative determination of drug interactions, where CI<1, =1, and >1 indicates synergism, additive effect and antagonism, respectively.

What kind of cancer can Chou Talalay be used for?

It is an orally bioavailable bi-aryl urea and pharmacologically-classified as a small molecule multi-kinase inhibitor for the treatment of hepatocellular carcinoma, renal cell carcinoma, and papillary and follicular thyroid cancers [ 8 ].

How many citations are there for Chou TC’s work?

Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27-55, 1984. (Cited 5,235 times in 778 different journals). Chou TC.