What is Retrosynthesis in organic chemistry?
Retrosynthesis is a method of chemical synthesis which involves “deconstructing” a target molecule into its readily available, simple starting materials in order to assess the best synthetic route. In doing so, the most favorable, efficient route can be chosen before synthesis is started on an industrial scale.
What are Synthons in Retrosynthesis?
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J.
What is disconnection approach Slideshare?
Disconnection: An analytical operation, which breaks a bond and converts a molecule into a possible starting material. The reverse of a chemical reaction.
What do you mean by Retrosynthesis and FGI in disconnection approach?
An approach for designing organic synthesis which involves breaking down of target molecule into available starting material by imaginary breaking of bonds (disconnection) and/ or by functional group interconversion (FGI) is known as disconnection approach or retrosynthetic analysis or retrosynthesis or synthesis …
What is Chemoselectivity in organic chemistry?
Chemoselectivity is a term that describes the ability of a reagent or intermediate to react with one group or atom in a molecule in preference to another group or atom present in the same molecule.
What is FGI give an example?
FGI: Functional Group Interconversion: The operation of writing one functional group for another so that disconnection becomes possible. The reverse of a chemical reaction. – imaginary breaking of bonds (disconnections) and by the conversion of one functional group into another (functional group interconversions).
What are Synthons and synthetic equivalents?
The key difference between synthon and synthetic equivalent is that synthon is a moiety of a chemical compound that can be formed by a known synthetic process, whereas synthetic equivalent is a reagent that carries out the function of a synthon.
What is one group CC disconnection?
Synthesis of alcoholic compounds by 1,1 C-C disconnections Any compound bearing an alcoholic group can be disconnected at the C-C bond adjacent to oxygen. The starting materials for these types of compounds are an aldehyde or ketone and Grignard reagent (Figure 2).
What is difference between Regioselectivity and chemoselectivity?
(i) Chemoselectivity is deciding which group reacts. (ii) Regioselectivity is where the reaction takes place in that group.
What is the target molecule in retrosynthesis?
Terminology O The target molecule (TM) is the H2N goal, the target, the molecule you are trying to make… target molecule retrosynthetic analysis reverse step disconnection synthon synthetic equivalent functional group interconversion terminology guidelines aromatics aliphatics two group patterns C–C bonds 8.
How is a retrosynthetic analysis used in a synthesis?
Retrosynthetic analysis is a technique for planning a synthesis, especially of complex organic molecules, whereby the complex target molecule (TM) is reduced into a sequence of progressively simpler structures (retrons) along a pathway which ultimately leads to the identification of a simple or commercially available starting material (SM) from
What are the symbols of retrosynthetic analysis 11?
Symbols of Retrosynthetic Analysis 11 A disconnection is represented by a wavy (⌇)line through the bond being disconnected,. A retrosynthetic arrow (⇒)represents going from the target molecule “backwards” to simpler molecules (retrons). A synthetic arrow ( ) represents going in the forward direction.
Which is the Best PowerPoint presentation for retrosynthesis?
Synthesis of Spirocyclic Compounds – Synthesis of Spirocyclic Compounds Yi He Introduction Synthetic methodologies Syntheses of spirocyclics in natural products Gelsemine Spirotryprostatin Synthesis of Spirocyclic Compounds Yi He Introduction Synthetic methodologies Syntheses of spirocyclics in natural products Gelsemine Spirotryprostatin