What is trimetazidine used for?
Trimetazidine belongs to the class of medications called fatty acid oxidation inhibitors. It is used to prevent and treat the symptoms of angina (chest pain). Angina is caused by lack of blood supply and oxygen to your heart.
How does trimetazidine work?
Trimetazidine is a cytoprotective drug that normalizes metabolic disturbances in low-flow ischemia via several—not yet fully understood—mechanisms of action. The best known trimetazidine mechanism of action is its capacity to inhibit β-oxidation of free fatty acid (FFA) [1].
What is trimetazidine side effects?
Trimetazidine has a significant side effects profile, with the most common adverse reactions being nausea, vomiting, fatigue, dizziness, and myalgia. The drug can induce or increase parkinsonian symptoms: extrapyramidal rigidity, bradykinesia, and tremor.
Can trimetazidine lower BP?
Unlike conventional drugs, trimetazidine exerts no effect on coronary flow, contractility, blood pressure, or heart rate.
Is trimetazidine good for the heart?
Previous studies have shown that trimetazidine improves cardiac function by improving hemodynamics; however, the protective effect of trimetazidine on ischemic heart failure is not entirely due to its effects on the hemodynamic system.
How long should trimetazidine be taken?
In conclusion, treatment with trimetazidine added to the usual treatment for up to 18 months was well tolerated and induced functional improvement in patients with ischaemic dilated cardiomyopathy. Trimetazidine treatment was associated with a significant improvement of LV function and the remodelling process.
How long will I take trimetazidine?
Does trimetazidine lower heart rate?
The dose of trimetazidine does not affect hemodynamic stability, heart rate, blood pressure and speed-pressure multiplication, and it exerts no negative inotropic effect.
What happens if you stop taking trimetazidine?
Discontinuing trimetazidine treatment in people with Parkinson’s disease may lessen their motor and non-motor symptoms and improve their quality of life, a study has found.
How long can I take trimetazidine?
No significant adverse event or changes in clinical or biochemical parameters were detected. Conclusion: Treatment with trimetazidine added to the usual treatment for up to 18 months was well tolerated and induced a functional improvement in patients with dilated cardiomyopathy.
What kind of drug is trimetazidine used for?
Trimetazidine is a drug for angina pectoris sold under many brand names. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization…
What kind of drug is trimetazidine for angina pectoris?
Trimetazidine is a drug for angina pectoris sold under many brand names. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent of the fatty acid oxidation inhibitor class,
What is the half life of trimetazidine Mr?
Half life of the modified release (MR) formulation was reported to be ∼8 h in young volunteers (25 ± 8) and ∼12 h in elderly (72 ± 4) (Barré et al. 2003).
Where does trimetazidine get its energy from?
The identity of trimetazidine’s target is controversial. In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable).